Malaria parasite-infected red blood cells: a renovator’s dream
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Biochemistry and Molecular Biology
- Bio21 Molecular Science and Biotechnology Institute
|Professor Leann Tilleyfirstname.lastname@example.org||0383442227||Personal web page|
|Dr Adam Blanchemail@example.com||+61383442255|
Summary This project will study host cell remodeling and key virulence determinants in P. falciparum, P. vivax and P. knowlesi both in mature erythrocytes and reticulocytes.
Are you interested in how and why malaria parasites cause pathology and death? The blood stages of Plasmodium are responsible for disease symptoms, but the symptoms and virulence differ for different species of the malaria parasite. This reflects the fact that different species of plasmodium adopt different strategies to ensure survival in the bloodstream. It is becoming clear, however, that in each case they do so by altering the properties of the erythrocytes they infect. This project will study host cell remodeling and key virulence determinants in P. falciparum, P. vivax and P. knowlesi both in mature erythrocytes and reticulocytes. In work leading to this project we have developed new imaging methods to examine the organisation of infected erythrocytes at the highest possible resolution. The work combines molecular and cell biology, biophysical techniques, including generation and use of microfluidic chips, and microscopy techniques such as super-resolution light microscopy and electron microscopy to elucidate the ways in which parasites subvert their host cells. The work aims to try to find ways to interfere with this process and thus combat virulence.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research NodeBio21 Molecular Science and Biotechnology Institute
MDHS Research library
Explore by researcher, school, project or topic.