Investigating the molecular basis of central myelination and repair

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Department
Anatomy and Neuroscience
Location
Medical Building
Primary Supervisor Email Number Webpage
Dr Junhua Xiao xiaoj@unimelb.edu.au +61 3 9035 9759 Personal web page

Summary This project will involve the analysis of the myelin-forming oligodendrocytes and their capacity of myelin repair as well as functional recovery in cell-type specific mouse mutant in combination with animal models of demyelinating diseases.

Project Details

Myelin, the membrane surrounding many axons in the nervous system, is vital for normal sensory, motor and cognitive functions.  Myelin damage is commonly observed in many neurological disorders including multiple sclerosis, Alzheimer’s disease, peripheral neuropathies etc.  Indeed, remyelination failure remains a major obstacle to recovery in many neurological diseases., for which no specific therapies are currently available.

Our lab primarily focuses on understanding the molecular and cellular mechanisms that regulate peripheral and central nervous system myelination in order to develop new myelin repair therapies for demyelinating diseases such as Multiple Sclerosis. Using a wide range of in vitro and in vivo models, we are examining extrinsic (environmental) and intrinsic (intracellular) factors that govern the production and development of Schwann cells and oligodendrocytes, in particular the function of oligodendrocytes following central nervous system injury.

Figure 1: Schematic showing oligodendroglial lineage development and de novo myelination



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease, Therapeutics & Translation



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Anatomy and Neuroscience

Research Group / Unit / Centre

Murray & Xiao laboratory: Neurotrophin and myelin

Research Node

Medical Building

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