Investigating the molecular basis of central myelination and repair
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Anatomy and Neuroscience
- Medical Building
|Dr Junhua Xiaoemail@example.com||+61 3 9035 9759||Personal web page|
Summary This project will involve the analysis of the myelin-forming oligodendrocytes and their capacity of myelin repair as well as functional recovery in cell-type specific mouse mutant in combination with animal models of demyelinating diseases.
Myelin, the membrane surrounding many axons in the nervous system, is vital for normal sensory, motor and cognitive functions. Myelin damage is commonly observed in many neurological disorders including multiple sclerosis, Alzheimer’s disease, peripheral neuropathies etc. Indeed, remyelination failure remains a major obstacle to recovery in many neurological diseases., for which no specific therapies are currently available.
Our lab primarily focuses on understanding the molecular and cellular mechanisms that regulate peripheral and central nervous system myelination in order to develop new myelin repair therapies for demyelinating diseases such as Multiple Sclerosis. Using a wide range of in vitro and in vivo models, we are examining extrinsic (environmental) and intrinsic (intracellular) factors that govern the production and development of Schwann cells and oligodendrocytes, in particular the function of oligodendrocytes following central nervous system injury.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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