Investigating the contributions of the vagus nerve to cardiovascular control via intraneural recordings from the cervical vagus nerve in humans

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Vaughan Macefield vaughan.macefield@baker.edu.au
Co-supervisor Email Number Webpage
Dr Tye Dawood

Summary While we have learnt much about the role of the sympathetic nervous system in cardiovascualr control from direct intraneural recordngs of muscle sympathetic nerve actiivity (MSNA) in humans, our understanding of the contributions of the parasympathetic nervous system to control of the heart is indirect, based largely on assessment of heart rate variability (HRV).

Project Details

While we have learnt much about the role of the sympathetic nervous system in cardiovascualr control from direct intraneural recordngs of muscle sympathetic nerve actiivity (MSNA) in humans, our understanding of the contributions of the parasympathetic nervous system to control of the heart is indirect, based largely on assessment of heart rate variability (HRV). Now, for the first time, we have succeeded in making single-unit recordings from the human vagus nerve, by inserting a tungsten microelectrode  through the skin of the neck and directing it into the nerve under ultrasound guidance. We have obtained preliminary data on the behaviour of cardiac parasympathetic axons but there is much to learn about the behaviour of the  low-pressure baroreceptors in the atria and high-presure baroreceptors in the aortic arch, for example.  Aspects of this study will suit an Honours project, or more in-depth investigation would suit a Masters or PhD project.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


MDHS Research library
Explore by researcher, school, project or topic.