Investigating the autophagy pathway in a novel C9ORF72 mouse model of motor neuron disease

Research Opportunity
PhD students, Honours students
Number of Honour Places Available
1
Primary Supervisor Email Number Webpage
A/Prof Bradley Turner bradley.turner@florey.edu.au
Co-supervisor Email Number Webpage
Dr Nirma Perera

Summary The Turner lab is interested in modelling neurodegenerative diseases affecting the motor system using patient stem cell and animal models, spanning pediatric and adult motor neuron diseases.

Project Details

Motor neuron disease (MND) is a neurodegenerative disease characterised by cytoplasmic accumulation and aggregation of proteins which are implicated in motor neuron death.  Strategies that improve proteostasis and clear these misfolded proteins in motor neurons are therefore an attractive therapeutic approach for MND.  Our group is interested in autophagy, the main catabolic pathway in neurons that targets and degrades misfolded proteins, aggregates and damaged organelles.  C9ORF72 mutation is the largest genetic cause of MND affecting 40% of familial MND cases and 8-10 % of sporadic ALS. This project will investigate the autophagy pathway in a novel C9ORF72 mouse model and will employ advanced microscopy, immunohistological and image analysis techniques.



Research Opportunities

PhD students, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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