Investigating the anti-inflammatory effects of deleting a gene in neurons

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Jenny Gunnersen jenny.gunnersen@unimelb.edu.au

Summary The Neuron Development and Plasticity group, led by Jenny Gunnersen, has the broad research goal of understanding how neurons become connected into functional circuits.

Project Details

Our recent data indicate that Sez6 proteins are linked to inflammation. Firstly, Sez6 levels are elevated in cerebrospinal fluid from surgical patients with chronic, painful inflammatory conditions, compared to those in patients attending the hospital emergency department for acute conditions. Secondly, quantitative proteomics of brain extracts from mice lacking Sez6 family proteins indicates that pro-inflammatory signalling pathways are less active in the absence of Sez6 proteins. This project will use biochemical and histochemical methods and flow cytometry to investigate these links.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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