Investigating Alcohol-Related Dementia

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
Number of Master Places Available
Primary Supervisor Email Number Webpage
Dr Christina Perry
Co-supervisor Email Number Webpage
Prof Andrew Lawrence

Summary The Addiction Neuroscience Laboratory at Florey Institute of Neuroscience and Mental Health. Our overarching research aim is to understand the brain mechanisms that drive drug and alcohol-seeking, and relapse to drug-seeking after a period of abstinence. We are also interested in the effects of chronic drug and alcohol intake on cognition and behaviour. Our lab employs a range of different behavioural and molecular techniques to investigate cellular and circuitry changes that occur as a result of exposure to drugs and alcohol, and how these changes may lead to the compulsive behaviour that is characteristic of addiction.

Project Details

Alcohol-related dementia (ARD) is one of the leading causes of secondary (preventable) dementia, and younger onset dementia (onset of symptoms prior to 65 years) in Australia. Together with the high rates of alcohol consumption in Australia, this means that ARD is becoming an increasingly urgent public health issue. The only treatment currently available for ARD is alcohol rehabilitation and abstinence.  However, emerging evidence from animal models indicates that exercise may act as a protective factor against the neurotoxic effects of alcohol, and is even able to reverse some of the brain injury that occurs following alcohol exposure.The aim of this project is to use a validated rodent model to:1) Characterise the cognitive and neuropathological symptoms of ARD.2) Evaluate the restorative effects of abstinence combined with voluntary exercise on these symptoms.

Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

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