Investigate how mutations in Syt1 affect the synaptic vesicle cycle, and whether these effects are treatable

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Sarah Gordon sarah.gordon@florey.edu.au

Summary Presynaptic dysfunction in neurodevelopmental disorders. Neurodevelopmental disorders are a devastating group of conditions characterised by developmental impairments, which usually manifest in infants and children. These disorders can result in a broad range of deficits, including learning delay and intellectual disability, problems with muscle control and movement, and behavioural and emotional issues. In severe cases the affected individuals may require lifetime care and/or have a reduced life expectancy.

Project Details

This project will examine whether all Syt1 mutations cause the same alterations to neurotransmitter release dynamics, thereby determining the molecular mechanisms underlying neurodevelopmental disorders in individuals harbouring these mutations.

Intriguingly, mutations in the related protein, synaptotagmin-2, cause a neuromuscular disorder which is treatable. We will investigate whether pharmacological intervention with this same drug can at least partially overcome some of the deficits caused by mutations in Syt1.

This project will implement a variety of techniques, including molecular biology, biochemistry, primary neuronal cell culture, fixed immunofluorescence imaging and live-cell fluorescent imaging, giving students the opportunity to master a range of key transferrable skills.




Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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