Investigate how alpha synuclein regulates the synaptic vesicle cycle and neurotransmitter release

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Sarah Gordon sarah.gordon@florey.edu.au

Summary Presynaptic dysfunction in neurodevelopmental disorders. Neurodevelopmental disorders are a devastating group of conditions characterised by developmental impairments, which usually manifest in infants and children. These disorders can result in a broad range of deficits, including learning delay and intellectual disability, problems with muscle control and movement, and behavioural and emotional issues. In severe cases the affected individuals may require lifetime care and/or have a reduced life expectancy.

Project Details

Alpha synuclein has been proposed to modulate various aspects of the synaptic vesicle cycle. Importantly, it controls the presynaptic targeting of a key synaptic vesicle protein, synaptobrevin II, which is crucial for neurotransmitter release. This project will determine how alpha synuclein regulates the localisation and function of synaptobrevin II and the implications this has for synaptic vesicle dynamics and neurotransmitter release.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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