Intracellular trafficking in neurons and Alzheimer's disease

Summary Membrane trafficking underpins many cell processes, including secretion, receptor signalling, endocytosis, antigen presentation, and neural networking. Many diseases arise from defects in membrane trafficking, including Alzheimer’s disease. Our aim is to understand the molecular basis of membrane and protein sorting in the secretory and endocytic pathways in a variety of physiological processes using cultured cells and differentiated primary cells, and to exploit this knowledge for the design of new therapeutics.