Interrogating B cell immunity to influenza vaccines

Research Opportunity
PhD, Masters by Research
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Stephen Kent skent@unimelb.edu.au (03) 8344 9939 Personal web page
Co-supervisor Email Number Webpage
Dr Adam Wheatley a.wheatley@unimelb.edu.au
Dr Hyon-Xhi Tan Hyon-Xhi Tan hxtan@unimelb.edu.au

Summary This project will utilise advanced microscopy and flow cytometry-based techniques to interrogate influenza-specific B cell responses (memory B cells, antibodies) to infection and immunisation in both relevant animal models of human influenza, and human clinical samples. Insights will be used to guide the design and testing of novel influenza vaccine concepts in animal models.

Project Details

Influenza remains a persistent threat to human health, with current vaccines eliciting sub-optimal and transient protection from infection. Mechanistically, vaccine protection is afforded by antibodies targeting a cluster of highly variable sites in the viral entry protein hemagglutinin (HA). However, next-generation vaccines seek to expand immune recognition to alternative sites within HA, or alternative viral proteins, in order to increase protective breadth. This project will utilise advanced microscopy and flow cytometry-based techniques to interrogate influenza-specific B cell responses (memory B cells, antibodies) to infection and immunisation in both relevant animal models of human influenza, and human clinical samples. Insights will be used to guide the design and testing of novel influenza vaccine concepts in animal models.




Research Opportunities

PhD, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy

Research Node

Doherty Institute

MDHS Research library
Explore by researcher, school, project or topic.