Interrogating B cell immunity to influenza vaccines
- Research Opportunity
- PhD students, Masters by Research
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
Primary Supervisor | Number | Webpage | |
---|---|---|---|
Professor Stephen Kent | skent@unimelb.edu.au | (03) 8344 9939 | Personal web page |
Co-supervisor | Number | Webpage | |
---|---|---|---|
Dr Adam Wheatley | a.wheatley@unimelb.edu.au | ||
Dr Hyon-Xhi Tan Hyon-Xhi Tan | hxtan@unimelb.edu.au |
Summary This project will utilise advanced microscopy and flow cytometry-based techniques to interrogate influenza-specific B cell responses (memory B cells, antibodies) to infection and immunisation in both relevant animal models of human influenza, and human clinical samples. Insights will be used to guide the design and testing of novel influenza vaccine concepts in animal models.
Project Details
Influenza remains a persistent threat to human health, with current vaccines eliciting sub-optimal and transient protection from infection. Mechanistically, vaccine protection is afforded by antibodies targeting a cluster of highly variable sites in the viral entry protein hemagglutinin (HA). However, next-generation vaccines seek to expand immune recognition to alternative sites within HA, or alternative viral proteins, in order to increase protective breadth. This project will utilise advanced microscopy and flow cytometry-based techniques to interrogate influenza-specific B cell responses (memory B cells, antibodies) to infection and immunisation in both relevant animal models of human influenza, and human clinical samples. Insights will be used to guide the design and testing of novel influenza vaccine concepts in animal models.
Research Opportunities
PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy
Research Node
Doherty InstituteMDHS Research library
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