Infection induced changes to splenic macrophages
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Lynette Beattie | lynette.beattie@unimelb.edu.au | 8344 5690 | Personal web page |
Summary We previously showed that as a result of infection with blood stage malaria parasites, we see a CD8 T cell-mediated loss of two of the populations of macrophages, associated with a breakdown in the splenic architecture. We are now investigating this further to understand the how CD8 T cells mediate this effect and determine if it has functional consequences for the development of immunity.
Project Details
There are multiple populations of macrophages in the spleen which all have unique locations and functions. We previously showed that as a result of infection with blood stage malaria parasites, we see a CD8 T cell-mediated loss of two of the populations of macrophages, associated with a breakdown in the splenic architecture. We are now investigating this further to understand the how CD8 T cells mediate this effect and determine if it has functional consequences for the development of immunity. This project will use advanced cellular immunology techniques including live imaging, immunohistology and flow cytometry.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity
Research Node
Doherty InstituteMDHS Research library
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