Infection induced changes to splenic macrophages

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Lynette Beattie lynette.beattie@unimelb.edu.au 8344 5690 Personal web page

Summary We previously showed that as a result of infection with blood stage malaria parasites, we see a CD8 T cell-mediated loss of two of the populations of macrophages, associated with a breakdown in the splenic architecture. We are now investigating this further to understand the how CD8 T cells mediate this effect and determine if it has functional consequences for the development of immunity.

Project Details

There are multiple populations of macrophages in the spleen which all have unique locations and functions. We previously showed that as a result of infection with blood stage malaria parasites, we see a CD8 T cell-mediated loss of two of the populations of macrophages, associated with a breakdown in the splenic architecture. We are now investigating this further to understand the how CD8 T cells mediate this effect and determine if it has functional consequences for the development of immunity. This project will use advanced cellular immunology techniques including live imaging, immunohistology and flow cytometry.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity

Research Node

Doherty Institute

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