Immunoregulatory functions of the MARCH family of ubiquitin ligases
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Jose Villadangos | j.villadangos@unimelb.edu.au | (03) 9035 7684 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| A/Prof Justine Mintern |
Summary This project will employ biochemical techniques, microscopy, proteomics, and CRISPR-Cas9 technology to characterise the function of the MARCH family; identify novel MARCH substrates; and characterise the machinery involved in ubiquitination by MARCHs.
Project Details
Protein localisation and abundance (proteostasis) are controlled in eukaryotic cells by regulatory pathways, which remain poorly understood. These pathways regulate changes in protein expression or localisation, in response to environmental cues such as the presence of pathogens. Addition of the small protein ubiquitin (Ub) to membrane proteins by the membrane-associated RING-CH (MARCH) family of ligases is an important mechanism of control of membrane immunoreceptors. This project will employ biochemical techniques, microscopy, proteomics, and CRISPR-Cas9 technology to characterise the function of the MARCH family; identify novel MARCH substrates; and characterise the machinery involved in ubiquitination by MARCHs. The MARCHs have also been shown to play an important role in control of infection by HIV and other enveloped viruses. Our goal is to develop novel therapeutic approaches to fight infection based on manipulation of membrane protein ubiquitination.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research Node
Doherty InstituteMDHS Research library
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