The machines and pathways that facilitate mitochondrial protein import in human cells

Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Dr Diana Stojanovski d.stojanovski@unimelb.edu.au

Summary THE STOJANOVSKI GROUP is working to understand the inner workings of one of the cells most intriguing and important organelles, the Mitochondrion. Mitochondria are the cell’s power plant, where sugars from the food we eat are converted into energy that our bodies need to survive. Our lab is interested in how mitochondria are created and how they function in health, but also situations of dysfunction that lead to disease.  

Project Details

Inside each mitochondrion is a workforce of approximately 1500 proteins, which collaborate to perform the many critical functions of the organelle. These proteins are trafficked from their site of synthesis in the cytosol to their correct location within mitochondria, a process referred to as 'protein import'. If mitochondrial protein import fails, energy production and general mitochondrial health and function is affected. Therefore, not surprisingly dysfunctional protein import is linked to mitochondrial disease and other human pathologies. In spite of this, our understanding of mitochondrial protein import and import machineries in human cells remains poor. 

School Research Themes

Cell Signalling



Key Contact

For further information about this research, please contact a supervisor.

Research Node

Bio21 Molecular Science and Biotechnology Institute

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