Immuno-paralysis following severe infections or trauma
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Jose Villadangos | j.villadangos@unimelb.edu.au | (03) 9035 7684 | Personal web page |
Summary In this project we will use models of infection and trauma to characterise the mechanisms that cause dendritic cell paralysis and to develop therapies to prevent immunosuppression.
Project Details
Systemic Inflammatory Response Syndrome (SIRS) is a common condition associated with severe infections and trauma. It is characterised by inflammation followed by a period of immunosuppression that can last for several weeks. Immunosuppressed patients are at risk of suffering secondary or opportunistic infections, a major cause of death in intensive care units. Impairment of dendritic cells (DC), the primary initiators of T cell immunity, plays a prominent role in this immunosuppression post-SIRS. In this project we will use models of infection and trauma to characterise the mechanisms that cause DC paralysis and to develop therapies to prevent immunosuppression.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research Node
Doherty InstituteMDHS Research library
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