Immuno-paralysis following severe infections or trauma

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Jose Villadangos j.villadangos@unimelb.edu.au (03) 9035 7684 Personal web page

Summary In this project we will use models of infection and trauma to characterise the mechanisms that cause dendritic cell paralysis and to develop therapies to prevent immunosuppression.

Project Details

Systemic Inflammatory Response Syndrome (SIRS) is a common condition associated with severe infections and trauma. It is characterised by inflammation followed by a period of immunosuppression that can last for several weeks. Immunosuppressed patients are at risk of suffering secondary or opportunistic infections, a major cause of death in intensive care units. Impairment of dendritic cells (DC), the primary initiators of T cell immunity, plays a prominent role in this immunosuppression post-SIRS. In this project we will use models of infection and trauma to characterise the mechanisms that cause DC paralysis and to develop therapies to prevent immunosuppression.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer

Research Node

Doherty Institute

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