Immunity, Chronic Inflammation and Cardiovascular Disease

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Karlheinz Peter karlheinz.peter@baker.edu.au
Co-supervisor Email Number Webpage
Dr Jonathon Noonan

Summary The Peter and Wang group focuses on basic and translational research covering a wide variety of themes, including cardiovascular disease, autoimmunity and cancer

Project Details

The Peter and Wang group focuses on basic and translational research covering a wide variety of themes, including cardiovascular disease, autoimmunity and cancer. We study fundamental disease mechanisms in order to define the key cells and molecules which contribute to the development or outcome of disease. Using this information, we then design, test and implement novel molecular imaging approaches using state of the art technologies (magnetic resonance imaging, ultrasound, computed tomography, positron-emission tomography and 3D fluorescence emission computed tomography). We focus on novel therapeutic approaches, such as biological therapies targeting immune cells; and theranostics, which combine both therapeutics and diagnostics into a single platform.

Atherosclerosis is a disease characterised by the formation of chronically inflamed lipid laden plaques in medium and large arteries, such as those that supply the heart and brain with blood. The rupture of these plaques causes blood clots which can block these arteries, and is the primary cause of myocardial infarction (heart attacks), strokes, and the majority of cardiovascular disease mortality. Despite recognition that inflammation is a key feature of atherosclerosis and the most likely cause of plaque rupture, it is not fully understood what drives the chronicity of pro-atherosclerotic immune responses. With a particular focus on the adaptive immune system (T & B cells); we aim to deeply characterise the immune landscape in atherosclerosis using state-of-the-art technologies, identify the causes of immune dysregulation and chronic atherosclerotic inflammation and define the role these pathways play in the development and outcome of cardiovascular disease. There is the opportunity to pursue several avenues for research projects, including: 1)Deep characterisation of adaptive immune responses in human and murine cardiovascular disease. 2) Defining the role of sexual dimorphism in the immune response in cardiovascular disease. 3) The role of conventional vs unconventional T cells in atherosclerosis and myocardial infarction. 4)Modulating adaptive immunity for the treatment of cardiovascular disease. 




Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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