Illuminating microbial “dark matter” for antibiotic discovery

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Sacha Pidot sacha.pidot@unimelb.edu.au 9035 3129 Personal web page
Co-supervisor Email Number Webpage
Professor Tim Stinear tstinear@unimelb.edu.au 8344 5693 Personal web page

Summary This project will investigate the potential for antimicrobial production through co-culturing and induction across a range of actinomycete bacteria, testing for their ability to inhibit hospital superbugs, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Students taking on this project will gain skills across the areas of genomics, molecular biology, biochemistry and mass spectrometry.

Project Details

The discovery of new antibiotics to combat the rising tide of antibiotic resistant bacteria has been hampered by the rediscovery of commonly encountered antibiotic compounds from soil bacteria. Genomics, however, has shown us that the well of antimicrobials is not yet dry and there are many more potential compounds left to find. To do this, however, new approaches are required. Recently, the incubation of different bacteria in co-culture or growth in the presence of sub-inhibitory concentrations of antibiotics has been shown to induce antibiotic production. This project will investigate the potential for antimicrobial production through co-culturing and induction across a range of actinomycete bacteria, testing for their ability to inhibit hospital superbugs, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Students taking on this project will gain skills across the areas of genomics, molecular biology, biochemistry and mass spectrometry.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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