Identifying novel subsets of immune cells that control cytomegalovirus following transplantation
- Research Opportunity
- PhD, Masters by Research, Honours
- Microbiology and Immunology
- Doherty Institute
|Dr Lucy Sullivanfirstname.lastname@example.org||(03) 8344 5708||Personal web page|
|Dr Michelle Yong|
|Dr Sanda Stankovicemail@example.com|
Summary We wish to investigate the role of immune cells in controlling cytomegalovirus (CMV) following transplantation. We anticipate our research can lead to improved diagnostic tests that provide a more accurate and comprehensive assessment of CMV immunity.
Transplantation is a life-saving procedure for people with end-stage organ failure or malignant blood cancers. However, post-transplant immunosuppressive medications, required to prevent rejection, result in impaired ability to control infections. In particular, the control of cytomegalovirus (CMV) is one of the most significant hurdles to successful transplantation. Anti-viral pre-emptive therapies are routinely used, often for an uncertain duration and frequently causing bone marrow or renal toxicity. CMV-immune monitoring assays can optimise the duration of anti-viral prophylaxis, by giving an indication of when the individual patient has sufficient CMV-immunity to prevent disease. However, our preliminary data indicates that several important immune cell populations are overlooked in CMV immune monitoring assays. We now wish to investigate the role of these immune cells in controlling CMV following transplantation. We anticipate our research can lead to improved diagnostic tests that provide a more accurate and comprehensive assessment of CMV immunity. Moreover, we may be able to harness novel immune cells for focused therapies with a view to reducing CMV and prolonging survival following transplantation.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
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Research NodeDoherty Institute
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