Identification of novel regulators of stem cell differentiation
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- 2
- Number of Master Places Available
- 2
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Prof Gary Hime | g.hime@unimelb.edu.au |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Nicole Siddall |
Summary The Hime groups studies regulation of organ development and regeneration in Drosophila and vertebrate tissues. Many differentiated but renewable cell types are derived from relatively small populations of dedicated precursors, or stem cells. The ability to replenish differentiated cells depends on the continued survival and proliferation of their respective stem cell populations. If we are to realise the goals of re-programming tissue differentiation, growing organs for transplantation in vitro, regeneration of damaged organs in vivo and targeted effective treatments for cancer it is essential that we understand the molecules and mechanisms that stem cells utilise for renewal and differentiation.
Project Details
We have conducted genetic screens which have identified new mutations that affect the ability of Drosophila male germline stem cells to differentiate. This project will involve genetic analysis and DNA sequencing to identify genes associated with specific mutations and phenotypic characterization of the mutant to determine the mechanism affecting stem cell differentiation. See Dominado et al (2016) and Monk et al (2010).Research Opportunities
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
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