Identification and characterisation of novel malarial transmission-blocking antigens

Research Opportunity
Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Siddhartha Mahanty smahanty@unimelb.edu.au (03) 8344 1972 Personal web page
Co-supervisor Email Number Webpage
Professor Stephen Rogerson sroger@unimelb.edu.au (03) 8344 3259 Personal web page

Summary We propose to characterise the sexual stage Ab targets in Plasmodium falciparum, the cause of the most severe form of malaria, and to better understand the properties of Abs that confer transmission blocking immunity (TBI).

Project Details

How do antibodies against Plasmodium falciparum gametocytes induce transmission blocking immunity? Immunity against the sexual stage, that underpin transmission-blocking vaccines (TBV) directed at parasite molecules expressed in the gametocyte through to ookinete stages, are not well-understood. Antibodies (Ab) directed against these molecules are likely be crucial for transmission blocking immunity (TBI). We propose to characterise the sexual stage Ab targets in Plasmodium falciparum, the cause of the most severe form of malaria, and to better understand the properties of Abs that confer TBI. The goals of this project are to identify previously unidentified antigens and functionally characterise anti-gametocyte antibodies in sera from malaria-infected individuals that mediate TBI using biochemical and immunological techniques.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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