How is selective metal ion transport achieved at the host-pathogen interface?
- Research Opportunity
- PhD, Honours
- Microbiology and Immunology
- Doherty Institute
|Associate Professor Christopher McDevittfirstname.lastname@example.org||(03) 8344 7200||Personal web page|
|Dr Alex Carey Hulyeremail@example.com||8344 0825|
Summary Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface.
Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface. Recent studies from our group have shown that many bacterial metal ion transporters are not restricted to solely interacting with the ion(s) that they import. These observations have challenged the prevailing dogma for how biological selectivity of metals is achieved. To resolve this question, this project will use state-of-the-art methods, including single molecule FRET, electron paramagnetic resonance spectroscopy and reconstituted proteoliposomes, to reveal how bacterial metal ion transporters achieve selectivity for their physiological substrates.
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Research Group / Unit / Centre
Research NodeDoherty Institute
MDHS Research library
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