How is selective metal ion transport achieved at the host-pathogen interface?

Research Opportunity
PhD, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Christopher McDevitt christopher.mcdevitt@unimelb.edu.au (03) 8344 7200 Personal web page
Co-supervisor Email Number Webpage
Dr Alex Carey Hulyer alex.careyhulyer@unimelb.edu.au 8344 0825

Summary Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface.

Project Details

Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface. Recent studies from our group have shown that many bacterial metal ion transporters are not restricted to solely interacting with the ion(s) that they import. These observations have challenged the prevailing dogma for how biological selectivity of metals is achieved. To resolve this question, this project will use state-of-the-art methods, including single molecule FRET, electron paramagnetic resonance spectroscopy and reconstituted proteoliposomes, to reveal how bacterial metal ion transporters achieve selectivity for their physiological substrates.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

McDevitt laboratory

Research Node

Doherty Institute

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