How is selective metal ion transport achieved at the host-pathogen interface?
- Research Opportunity
- PhD, Honours
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Associate Professor Christopher McDevitt | christopher.mcdevitt@unimelb.edu.au | (03) 8344 7200 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Alex Carey Hulyer | alex.careyhulyer@unimelb.edu.au | 8344 0825 |
Summary Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface.
Project Details
Biological discrimination between metal ions remains poorly understood, yet essential to their function in the chemically complex environment of the host-pathogen interface. Recent studies from our group have shown that many bacterial metal ion transporters are not restricted to solely interacting with the ion(s) that they import. These observations have challenged the prevailing dogma for how biological selectivity of metals is achieved. To resolve this question, this project will use state-of-the-art methods, including single molecule FRET, electron paramagnetic resonance spectroscopy and reconstituted proteoliposomes, to reveal how bacterial metal ion transporters achieve selectivity for their physiological substrates.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Group / Unit / Centre
Research Node
Doherty InstituteMDHS Research library
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