How infection and trauma cause dendritic cell paralysis and lethal immunosuppression

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Jose Villadangos j.villadangos@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Justine Mintern jmintern@unimelb.edu.au Personal web page

Project Details

Systemic Inflammatory Response Syndrome (SIRS) is a common condition associated with systemic or severe infections, trauma or stroke. It is characterised by excessive release of inflammatory cytokines that activate the innate and acquired immune system. Paradoxically, his enhanced state of responsiveness is followed by a long period of immunosuppression. The immunosuppressed patients are at risk of suffering secondary or opportunistic infections, which are a major contributor to morbidity and death in intensive care units.

Our work has shown thatr impairment of dendritic cells (DC), the primary initiators of T cell immunity, plays a prominent role in immunosuppression post-SIRS. The goal of this project is to characterise the mechanisms that cause DC paralysis and investigate therapies to prevent immunosuppression post-SIRS.

Further reading:

  • Wilson et al (2006) Nat. Immunol. 7: 165-172
  • Vega-Ramos et al (2014) Curr. Opin. Pharmacol. 17: 64-70
  • Roquilly et al (2017) Immunity 47:135-147.


Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Biomedicine, Infection & Immunity, Molecular Mechanisms of Disease



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer

Research Node

Doherty Institute

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