How infection and trauma cause dendritic cell paralysis and lethal immunosuppression
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Microbiology and Immunology
- Doherty Institute
|Professor Jose Villadangosemail@example.com||Personal web page|
|Dr Justine Minternfirstname.lastname@example.org||Personal web page|
Systemic Inflammatory Response Syndrome (SIRS) is a common condition associated with systemic or severe infections, trauma or stroke. It is characterised by excessive release of inflammatory cytokines that activate the innate and acquired immune system. Paradoxically, his enhanced state of responsiveness is followed by a long period of immunosuppression. The immunosuppressed patients are at risk of suffering secondary or opportunistic infections, which are a major contributor to morbidity and death in intensive care units.
Our work has shown thatr impairment of dendritic cells (DC), the primary initiators of T cell immunity, plays a prominent role in immunosuppression post-SIRS. The goal of this project is to characterise the mechanisms that cause DC paralysis and investigate therapies to prevent immunosuppression post-SIRS.
- Wilson et al (2006) Nat. Immunol. 7: 165-172
- Vega-Ramos et al (2014) Curr. Opin. Pharmacol. 17: 64-70
- Roquilly et al (2017) Immunity 47:135-147.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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Research Group / Unit / Centre
Research NodeDoherty Institute
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