How does ageing effect antibody responses?

Research Opportunity
Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Amy Chung awchung@unimelb.edu.au (03) 8344 9938 Personal web page
Co-supervisor Email Number Webpage
Dr Nichollas Scott nichollas.scott@unimelb.edu.au (03) 8344 6724 Personal web page
Professor Stephen Kent skent@unimelb.edu.au (03) 8344 9939 Personal web page

Summary This project aims to further understand the effect of ageing upon antibody responses using non-human primate models.

Project Details

Antibodies are a vital component of the immune response required for protection and control of infectious diseases. However, large changes can occur to the quality of an antibody response as a person grows older. One of the reasons for this change is glycosylation, where sugar structures are added to the antibody. Different glycan structures can determine how well the antibody activates surrounding innate immune cells to attack and eliminate invading pathogens. Intriguingly, within humans, large antibody glycan changes are observed within infants and elderly, which may contribute to why they are more susceptible to infection. This project aims to further understand the effect of ageing upon antibody responses using non-human primate models.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

MDHS Research library
Explore by researcher, school, project or topic.