Gamma delta T cells are important for malaria sporozoite vaccination

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Lynette Beattie lynette.beattie@unimelb.edu.au 8344 5690 Personal web page

Summary Plasmodium parasites which cause malaria are extremely complex pathogens, with a life cycle involving multiple stages within the mosquito vector and the human host. We have recently shown that gamma delta T cells are crucial to the generation of immunity to liver stage infection as without this cell population present, CD4 and CD8 T cell responses are severely impaired and are dissecting the role that they play in this system using a combination of cellular assays including flow cytometry, histology and live intravital imaging.

Project Details

Plasmodium parasites which cause malaria are extremely complex pathogens, with a life cycle involving multiple stages within the mosquito vector and the human host. Sterilising immunity that can successfully protect against the liver stage of infection has many benefits, including blocking progression to clinical disease and blocking transmission back to the mosquito vector. Due to the short time frame of liver infection prior to break out into the blood stage, it is extremely hard to generate sterilising liver stage immunity. We have recently shown that gamma deltaT cells are crucial to the generation of immunity to liver stage infection as without this cell population present, CD4 and CD8 T cell responses are severely impaired. We are dissecting the role that gamma delta T cells play in this system using a combination of cellular assays including flow cytometry, histology and live intravital imaging.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity

Research Node

Doherty Institute

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