Exploiting nanoparticles as vaccines

Research Opportunity
PhD, Honours, Master of Biomedical Science
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Dr Justine Mintern jmintern@unimelb.edu.au 83442976 Personal web page
Co-supervisor Email Number Webpage
Professor Jose Villadangos j.villadangos@unimelb.edu.au

Project Details

Nanoparticles have exciting potential to serve as modular therapeutic delivery systems that can target any cell type and carry any therapeutic peptide cargo. One emerging application for nanoparticles is their use as next generation vaccines. While there have been significant successes in vaccine research, there are still many remaining challenges including developing vaccines against chronic infections such as HIV, malaria, tuberculosis, together with exploiting the potential of vaccination to eliminate cancer.

To develop vaccines against chronic disease, nanoparticles are needed that can target the cells responsible for initiating immunity, dendritic cells, and release immunogenic peptides (antigen). Here, we will examine the potential of nanoparticles as carriers that enable effective vaccination. We will investigate how different nanoparticle formulations can be used to elicit immunity to infection and tumours. We will investigate caveospheres, biological nanoparticles consisting of vessicles derived from cell membranes, in addition to synthetic nanoparticles that can be designed with properties that enable manipulation of the endocytic pathway. Nanoparticles will be tested in immune assays including as vaccines against lymphoma and influenza virus infection.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Cancer in Biomedicine, Cell Signalling, Molecular Mechanisms of Disease



Research Opportunities

PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Mintern laboratory: Vaccine biology

Research Node

Bio21 Molecular Science and Biotechnology Institute

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