Understanding interactions between gut epithelial stem cells and enteric neurons
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research
- Anatomy and Neuroscience
- Medical Building
|Dr Lincon Stampfirstname.lastname@example.org||Personal web page|
|Dr Marlene Haoemail@example.com||Personal web page|
Summary This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. The role of epithelial stem cell-nerve communication, and the signalling pathways mediating it, are currently poorly understood.
This study, which includes novel co-culturing of organoids and enteric neurospheres, will identify signalling pathways and cellular mechanisms by which nerves influence the epithelia during homeostasis and ageing.
The outcome of the project will be a better understanding of the biology of the body’s most highly proliferative, long-lived stem cells; intestinal epithelial stem cells.
Dr Lincon Stamp, ARC DECRA Fellow
Dr Marlene Hao, ARC DECRA Fellow
Ms Annette Bergner, Senior Research Assistant
Yvette Wilson, Research Assistant
Professor Christine Wells, University of Melbourne
A/Prof. Helen Abud, Monash University
2015-2017 (extended until 31.12.18) NHMRC Project Grant. Cell therapies for enteric neuropathies - the essential next step
2018 CASS Foundation Med/Sci Grant. A gut feeling about therapies for glioma treatment
Hao MM, Foong JP, Bornstein JC, Li ZL, Vanden Berghe P, Boesmans W. Enteric nervous system assembly: Functional integration within the developing gut. Dev Biol. 2016; 417:168-81
Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nature Medicine. 2017; 23:49-59
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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