Drosophila models of human disease

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Gary Hime g.hime@unimelb.edu.au

Summary The Hime groups studies regulation of organ development and regeneration in Drosophila and vertebrate tissues. Many differentiated but renewable cell types are derived from relatively small populations of dedicated precursors, or stem cells. The ability to replenish differentiated cells depends on the continued survival and proliferation of their respective stem cell populations. If we are to realise the goals of re-programming tissue differentiation, growing organs for transplantation in vitro, regeneration of damaged organs in vivo and targeted effective treatments for cancer it is essential that we understand the molecules and mechanisms that stem cells utilise for renewal and differentiation.

Project Details

The rapid advances in sequencing of human genomes has identified many variant gene sequences that may be associated with genetic diseases. It can be difficult to unambiguously associate genetic variants with phenotypes without a direct assay. We are using Drosophila to model the effects of genetic variants associated with human disease to determine how the variants affect gene function.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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