How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?
- Research Opportunity
- PhD, Masters by Research, Honours
- Anatomy and Neuroscience
- Peter MacCallum Cancer Institute
|Dr Louise Chengemail@example.com||Personal web page|
Summary The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer.
Dr Louise Cheng, Research Project Leader & Head of Laboratory
Dr Patricia Jusuf, School of Biosciences, University of Melbourne
Froldi F, Pachnis P, Szuperák M, Costas O, Fernando T, Gould AP, Cheng LY. Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS. EMBO J, 2019. (Cover Image). PMID: 30804004
Vissers JHA#, Froldi F#, Schroder J, Papenfuss AT, Cheng LY*, Harvey KF* (2018). The Scalloped and Nerfin-1 transcription factors cooperate to maintain neuronal cell fate. Cell Rep. Nov 6;25(6): 1561-1567 (# equal contribution, *Joint senior authors). PMID: 30404010
Froldi F, Szuperak M, Weng CF, Shi W, Pappenfus T, Cheng LY (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes Dev. 29(2):129-143. PMID: 25593306
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (2011). Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. Cell. 146(3):435–447. PMID: 21816278
Faculty Research Themes
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PhD, Masters by Research, Honours
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Research Group / Unit / Centre
Research NodePeter MacCallum Cancer Institute
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