How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide?

Research Opportunity
PhD, Masters by Research, Honours
Department
Anatomy and Neuroscience
Location
Peter MacCallum Cancer Institute
Primary Supervisor Email Number Webpage
Dr Louise Cheng lcheng1@unimelb.edu.au Personal web page

Summary The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer.

Researchers

Dr Louise Cheng, Research Project Leader & Head of Laboratory

Collaborators

Dr Patricia Jusuf, School of Biosciences, University of Melbourne

Research Publications

Froldi F, Pachnis P, Szuperák M, Costas O, Fernando T, Gould AP, Cheng LY. Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS. EMBO J, 2019. (Cover Image). PMID: 30804004

Vissers JHA#, Froldi F#, Schroder J, Papenfuss AT, Cheng LY*, Harvey KF* (2018). The Scalloped and Nerfin-1 transcription factors cooperate to maintain neuronal cell fate. Cell Rep. Nov 6;25(6): 1561-1567 (# equal contribution, *Joint senior authors). PMID: 30404010

Froldi F, Szuperak M, Weng CF, Shi W, Pappenfus T, Cheng LY (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes Dev. 29(2):129-143. PMID: 25593306

Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (2011). Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. Cell. 146(3):435–447. PMID: 21816278



Faculty Research Themes

Cancer, Neuroscience

School Research Themes

Cancer in Biomedicine, Biomedical Neuroscience, Stem Cells



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Anatomy and Neuroscience

Research Group / Unit / Centre

Cheng laboratory: Stem cell and organ size control regulation

Research Node

Peter MacCallum Cancer Institute

MDHS Research library
Explore by researcher, school, project or topic.