Development of Novel antimalarial drugs

Research Opportunity
PhD, Masters by Research, Honours
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Professor Leann Tilley ltilley@unimelb.edu.au 0383442227 Personal web page

Project Details

Would you like to help develop new antimalarial drugs?  Each year, Plasmodium falciparum causes more than 200 million cases of malaria, and about 438,000 deaths. Because current antimalarial control is highly dependent on artemisinin combination therapies (ACTs), it is extremely concerning that decreased sensitivity has emerged to all currently used ACTs. In response to this impending crisis, the peak body, Medicines for Malaria Venture (MMV), has declared that novel targets for antimalarial therapies need to be identified and new drugs developed.

As an organism that undergoes rapid growth and cell division in an environment of high oxidative stress, the malaria parasite is very reliant on cellular remodelling processes. Two major pathways degrade cellular components in eukaryotic cells: the proteasome system and autophagy. In this Project, we will study these two pathways in Plasmodium to elucidate their roles, determine how their activities intersect and study the action of test inhibitors. This work will provide the basis for the development of new drugs.

The project will use molecular biology, live cell imaging, flow cytometry and biochemical methods.

Drug development



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Therapeutics & Translation



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials

Research Node

Bio21 Molecular Science and Biotechnology Institute

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