Determining the role of diet and microbiota in the progression of lupus

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Fabienne Mackay fabienne.mackay@unimelb.edu.au (03) 8344 2726 Personal web page
Co-supervisor Email Number Webpage
Dr William Figgett william.figgett@unimelb.edu.au (03) 8344 1589 Personal web page
Dr Catherine Kennedy catherinek@unimelb.edu.au (03) 9035 8195 Personal web page

Summary The role of the gut microbiome and the potential for diet-based therapies in Systemic Lupus Erythematosus (SLE) and their mechanisms of protection will be studied in this project, using SLE-prone mouse models, incorporating advanced methods of metabolomics and microbial metagenomics profiling.

Project Details

Systemic Lupus Erythematosus (SLE) is a debilitating autoimmune disease driven by aberrant B cells producing antibodies against self. This leads to inflammation and ultimately tissue destruction. Today we have no cure for SLE and the current treatments are symptom-focused. Recent advancements in the understanding of the importance of diet and gut microbiota point to a potential role for dietary intervention in the treatment of various autoinflammatory diseases. The role of the gut microbiome and the potential for diet-based therapies in SLE and their mechanisms of protection will be studied in this project, using SLE-prone mouse models, incorporating advanced methods of metabolomics and microbial metagenomics profiling.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer

Research Node

Doherty Institute

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