Designing new optogenetic tools for biomedical research

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Danny Hatters dhatters@unimelb.edu.au 83442530
Co-supervisor Email Number Webpage
Dr Craig Morton Personal web page

Project Details

Optogenetics describes the manipulation of gene or protein function using light.  This powerful technology has exploded in the last few years because it provides exquisite control of a range of biological functions in biomedical research.  In this project, we seek to develop a new way to control the activity of streptavidin using light.  Streptavidin binds with extremely high affinity to biotin and hence has been used as one of the best systems in biology to detect and/or capture specific protein:protein interactions.  Controlling its activity with light will provide a new way to target protein:protein interactions in a spatially controllable manner.  This project will build on prototype designs in the lab and test the efficacy of them for being regulated by light.  This will involve cloning genes, modeling protein structures, designing targeted mutations and testing activity in mammalian and bacterial cell culture systems.



Faculty Research Themes

Cancer, Infection and Immunology, Neuroscience

School Research Themes

Cancer in Biomedicine, Infection & Immunity, Biomedical Neuroscience, Cell Signalling



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Hatters laboratory: Protein misfolding and proteostasis in neurodegenerative diseases

Research Node

Bio21 Molecular Science and Biotechnology Institute

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