Designing new optogenetic tools for biomedical research
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Biochemistry and Molecular Biology
- Bio21 Molecular Science and Biotechnology Institute
|A/Prof Danny Hattersemail@example.com||83442530|
|Dr Craig Morton||Personal web page|
Summary In this project, we seek to develop a new way to control the activity of streptavidin using light.
Optogenetics describes the manipulation of gene or protein function using light. This powerful technology has exploded in the last few years because it provides exquisite control of a range of biological functions in biomedical research. In this project, we seek to develop a new way to control the activity of streptavidin using light. Streptavidin binds with extremely high affinity to biotin and hence has been used as one of the best systems in biology to detect and/or capture specific protein:protein interactions. Controlling its activity with light will provide a new way to target protein:protein interactions in a spatially controllable manner. This project will build on prototype designs in the lab and test the efficacy of them for being regulated by light. This will involve cloning genes, modeling protein structures, designing targeted mutations and testing activity in mammalian and bacterial cell culture systems.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeBio21 Molecular Science and Biotechnology Institute
MDHS Research library
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