Defining the molecular mechanisms underlying heart failure

Research Opportunity
PhD students, Master of Biomedical Science
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Lea Delbridge lmd@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Claire Curl

Summary The Cardiac Phenomics Laboratory research is about understanding how the heart response to stress can be managed to minimize the damaging impacts of a variety of disease conditions. We investigate responses of the working ‘pumping’ heart, of specialized muscle tissues and cells from different regions of the heart and of molecular signaling processes. As our name suggests, we look at how the cardiac ‘genome’ (the genetically defined heart) is translated in different stressor situations to create the ‘phenome’ (the structurally and functionally defined heart).

Project Details

Among the growing number of patients with heart failure, as many as half have heart failure with preserved ejection fraction (HFpEF). In this condition the signature symptoms relate to relaxation abnormality in diastole, which limit the cardiac output due to compromised ventricular filling. To date, clinical trials have yet to find an effective and specific treatment for this condition. This project will utilise our unique experimental models of HFpEF to investigate the underlying molecular changes that occur with HFpEF and aims to identify therapeutic targets for this disease. We work with clinical partners in developing specialized imaging methods to benchmark laboratory derived measures of diastolic dysfunction against patient characteristics.



Research Opportunities

PhD students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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