Defining the impact of recurrent adaptive mutations on staphylococcal antimicrobial resistance and pathogenesis
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Number of Honour Places Available
- 2
- Number of Master Places Available
- 2
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Ben Howden | bhowden@unimelb.edu.au | 8344 5701 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Tim Stinear | tstinear@unimelb.edu.au | 8344 5693 | Personal web page |
Summary In this project, techniques including whole genome sequencing, directed mutagenesis, Tn-seq, RNA-seq and high-throughput phenotypic screening will be used to unravel the molecular basis of antibiotic resistance and pathogenicity in this important human pathogen.
Project Details
Staphylococcus aureus is one of the major causes of human bacterial infection, with increasing antibiotic resistance making treatment difficult. Our laboratory has discovered a critical link between resistance to antibiotics and changes in host-pathogen interactions and has identified important convergent mutations by analysing thousands ofStaphylococcus aureus genomes. In this project, techniques including whole genome sequencing, directed mutagenesis, Tn-seq, RNA-seq and high-throughput phenotypic screening will be used to unravel the molecular basis of antibiotic resistance and pathogenicity in this important human pathogen.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine
Research Node
Doherty InstituteMDHS Research library
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