Defining the impact of recurrent adaptive mutations on staphylococcal antimicrobial resistance and pathogenesis

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
2
Number of Master Places Available
2
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Ben Howden bhowden@unimelb.edu.au 8344 5701 Personal web page
Co-supervisor Email Number Webpage
Professor Tim Stinear tstinear@unimelb.edu.au 8344 5693 Personal web page

Summary In this project, techniques including whole genome sequencing, directed mutagenesis, Tn-seq, RNA-seq and high-throughput phenotypic screening will be used to unravel the molecular basis of antibiotic resistance and pathogenicity in this important human pathogen.

Project Details

Staphylococcus aureus is one of the major causes of human bacterial infection, with increasing antibiotic resistance making treatment difficult. Our laboratory has discovered a critical link between resistance to antibiotics and changes in host-pathogen interactions and has identified important convergent mutations by analysing thousands ofStaphylococcus aureus genomes. In this project, techniques including whole genome sequencing, directed mutagenesis, Tn-seq, RNA-seq and high-throughput phenotypic screening will be used to unravel the molecular basis of antibiotic resistance and pathogenicity in this important human pathogen.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine

Research Node

Doherty Institute

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