Decoding the trafficking of immune receptors

Research Opportunity
PhD, Honours, Master of Biomedical Science
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Supervisor Email Number Webpage
Justine Mintern jmintern@unimelb.edu.au 83442976 Personal web page

Project Details

Ubiquitin is a protein tag that once attached to a substrate has important implications for its fate. Attachment of ubiquitin can change the intracellular trafficking route of the protein with important consequences for the cell. The ubiquitin chain attached is often termed a ubiquitin code and will differ for individual proteins. This project will investigate the role of ubiquitin in the tagging and trafficking of immunoreceptors. Specifically, it will investigate the MARCH family. MARCH are membrane associated E3 ligases that are responsible for attaching ubiquitin chains to substrate proteins embedded in membranes. How MARCH participate in controlling the intracellular trafficking of critical immune molecules in different immune and non immune cell types will be examined. In addition, this project will examine new MARCH substrates, how MARCH are regulated and determine the ubiquitin code generated by distinct MARCH family members. This project will use CRISPR/Cas9 methodology, flow cytometry and mass spectrometry to examine the role of ubiquitin in shuttling key immune molecules to specific destinations in the cell.



Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Biomedicine, Cell Signalling, Molecular Mechanisms of Disease, Infection & Immunity



Research Opportunities

PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Mintern laboratory: Vaccine biology

Research Node

Bio21 Molecular Science and Biotechnology Institute

MDHS Research library
Explore by researcher, school, project or topic.