Decoding the trafficking of immune receptors
- Research Opportunity
- PhD, Honours, Master of Biomedical Science
- Department
- Biochemistry and Molecular Biology
- Location
- Bio21 Molecular Science and Biotechnology Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Justine Mintern | jmintern@unimelb.edu.au | 83442976 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Jose Villadangos | j.villadangos@unimelb.edu.au |
Summary This project will investigate the role of ubiquitin in the tagging and trafficking of immunoreceptors. Specifically, it will investigate the MARCH family.
Project Details
Ubiquitin is a protein tag that once attached to a substrate has important implications for its fate. Attachment of ubiquitin can change the intracellular trafficking route of the protein with important consequences for the cell. The ubiquitin chain attached is often termed a ubiquitin code and will differ for individual proteins. This project will investigate the role of ubiquitin in the tagging and trafficking of immunoreceptors. Specifically, it will investigate the MARCH family. MARCH are membrane associated E3 ligases that are responsible for attaching ubiquitin chains to substrate proteins embedded in membranes. How MARCH participate in controlling the intracellular trafficking of critical immune molecules in different immune and non immune cell types will be examined. In addition, this project will examine new MARCH substrates, how MARCH are regulated and determine the ubiquitin code generated by distinct MARCH family members. This project will use CRISPR/Cas9 methodology, flow cytometry and mass spectrometry to examine the role of ubiquitin in shuttling key immune molecules to specific destinations in the cell.
Faculty Research Themes
Cancer, Infection and Immunology
School Research Themes
Cancer in Biomedicine, Cell Signalling, Molecular Mechanisms of Disease, Infection & Immunity
Research Opportunities
PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Biochemistry and Molecular Biology
Research Group / Unit / Centre
Mintern laboratory: Vaccine biology
Research Node
Bio21 Molecular Science and Biotechnology InstituteMDHS Research library
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