Cow antibodies that give the finger to HIV transmission

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Damian Purcell dfjp@unimelb.edu.au 8344 6753 Personal web page
Co-supervisor Email Number Webpage
Dr Behnaz Heydarchi

Summary This project will further characterise monoclonal antibody bNAbs we have isolated from vaccinated cows, and define the genetic evolution of the immunoglobulin genes during the immune response needed to form an effective protective antibody.

Project Details

Prophylactic HIV vaccines aim to elicit broad neutralising antibody (bNAb) at the sexual mucosa to block virus transmission. We were the first to find and publish that vaccination of dairy cows with HIV Envgp140 trimer vaccines can elicit broad and potent bNAb responses in vast scale in the colostrum milk. This was patented for use as a passive antibody-microbicide prevention against HIV-transmission and has been scaled up and developed for clinical testing with a commercial partner. This project will further characterise monoclonal antibody bNAbs we have isolated from vaccinated cows, and define the genetic evolution of the immunoglobulin genes during the immune response needed to form an effective protective antibody.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine

Research Node

Doherty Institute

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