“Clock-off time” for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Department
Pharmacology and Therapeutics
Primary Supervisor Email Number Webpage
Professor Alastair Stewart astew@unimelb.edu.au 8344 5675 Personal web page

Project Details

Casein kinase 1 d (CK1d) has been implicated as a major regulator of the biochemical oscillator that determines circadian rhythm. Whilst most researchers think of the system as operating from the suprachiasmatic nucleus, responding to light input, peripheral cells also demonstrate circadian rhythm. Our laboratory has implicated CK1d in signalling some of the fibrogenic and inflammatory actions of TGF-β, including the ability to switch off the antiinflammatory effects of glucocorticoids. In this project, you will characterise the anti-inflammatory potential of this drug class using human cells obtained from peripheral blood and/or from the airways. Methods will include immunoassay, real-time quantitative PCR, cell culture and high content screening using plate-based confocal microscopy (Operetta).



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Pharmacology and Therapeutics


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