Characterisation of antimicrobial resistance and virulence of novel staphylococcal lineages

Research Opportunity
PhD, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Steven Tong steven.tong@mh.org.au (03) 9342 9406 Personal web page
Co-supervisor Email Number Webpage
Professor Benjamin Howden https://www.doherty.edu.au/people/professor-benjamin-howden (03) 8344 5701 Personal web page

Summary This project will determine the likelihood and mechanism of generation of resistance to co-trimoxazole (a commonly used antibiotic) and the virulence of this ST5 clone in relation to other Staphylococcus aureus clones.

Project Details

We have recently described emerging lineages of Staphylococcus aureus and Staphylococcus argenteus in northern Australia. The ST5 Staphylococcus aureus lineage has acquired resistance to trimethoprim and appears to have a clinically virulent phenotype. This project will determine the likelihood and mechanism of generation of resistance to co-trimoxazole (a commonly used antibiotic) and the virulence of this ST5 clone in relation to other Staphylococcus aureus clones. For Staphylococcus argenteus, we have identified a lineage associated with invasive infections and seek to identify genomic elements that confer this phenotype.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Howden laboratory: Molecular epidemiology, genomics and pathogenesis of antimicrobial resistant bacteria

Research Node

Doherty Institute

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