Characterisation of antimicrobial resistance and virulence of novel staphylococcal lineages
- Research Opportunity
- PhD, Honours
- Microbiology and Immunology
- Doherty Institute
|Associate Professor Steven Tongemail@example.com||(03) 9342 9406||Personal web page|
|Professor Benjamin Howden||https://www.doherty.edu.au/people/professor-benjamin-howden||(03) 8344 5701||Personal web page|
Summary This project will determine the likelihood and mechanism of generation of resistance to co-trimoxazole (a commonly used antibiotic) and the virulence of this ST5 clone in relation to other Staphylococcus aureus clones.
We have recently described emerging lineages of Staphylococcus aureus and Staphylococcus argenteus in northern Australia. The ST5 Staphylococcus aureus lineage has acquired resistance to trimethoprim and appears to have a clinically virulent phenotype. This project will determine the likelihood and mechanism of generation of resistance to co-trimoxazole (a commonly used antibiotic) and the virulence of this ST5 clone in relation to other Staphylococcus aureus clones. For Staphylococcus argenteus, we have identified a lineage associated with invasive infections and seek to identify genomic elements that confer this phenotype.
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Research NodeDoherty Institute
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