Cell fates and cell states: analysis of enhancer dynamics during angiogenesis and lymphangiogenesis
- Research Opportunity
- PhD students, Honours students
- Number of Honour Places Available
|Prof Ben Hoganfirstname.lastname@example.org|
|Dr Elizabeth Mason|
Summary Cellular fates are regulated by key transcription factors during vascular development, angiogenesis and lymphangiogenesis. In recent decades, analysis of vascular cell fates, such as artery, vein and lymphatic fates, has uncovered key transcription factors and target enhancer elements that regulate tissue identity. Nevertheless, how transcription factors drive dynamic changes in vessel growth, dynamic enhancer activities, dynamic cell behaviours and cellular heterogeneity in the growing vasculature, remains to be determined. Live imaging reporters of enhancer activity during zebrafish vascular development offers a unique opportunity to approach these fundamental questions. This project will take advantage of a large-scale dataset recently generated in the Hogan lab using single cell ATAC-seq data to assess the developing vasculature of the zebrafish embryo. The project will clone and assess functional enhancers that are lineage specific, evolutionarily conserved and candidate elements that may control dynamic cell behaviours during new vessel formation. Transgenesis, molecular genetics and cellular resolution confocal imaging of zebrafish vasculature will be coupled with bioinformatics studies of enhancer conservation and prediction of key functional regulators.
PhD students, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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