CCVs: Clathrin-coated vesicles and Coxiella containing vacuoles
- Research Opportunity
- PhD, Honours
- Microbiology and Immunology
- Doherty Institute
|Dr Hayley Newtonemail@example.com||(03) 9035 6307||Personal web page|
Summary This project will address whether this process also involves clathrin light chain and other key components of classical clathrin-mediated trafficking.
Coxiella burnetii, the causative agent of Q fever, creates a unique replicative niche by modifying the human lysosome. One key feature of this vacuole is the recruitment of clathrin heavy chain to the vacuole membrane. Recruitment of this protein is important for intracellular success of Coxiella and vacuole expansion, through facilitation of autophagosome-vacuole fusion. We have identified several bacterial virulence factors that are involved in commandeering clathrin machinery. This project will address whether this process also involves clathrin light chain and other key components of classical clathrin-mediated trafficking. Key methodologies will include microscopy, tissue culture and protein biochemistry.
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Research NodeDoherty Institute
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