Can resident memory B cells in the lung protect against respiratory syncytial virus?

Research Opportunity
PhD, Masters by Research
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Stephen Kent skent@unimelb.edu.au (03) 8344 9939 Personal web page
Co-supervisor Email Number Webpage
Dr Adam Wheatley a.wheatley@unimelb.edu.au 9035 4179
Dr Hyon-Xhi Tan hxtan@unimelb.edu.au 8344 0764

Summary This project will assess if immunisation to establish antiviral memory B cells in the lung can combat RSV infection. It will involve: engineering novel influenza-based viral vectors to deliver RSV vaccine antigens, testing in animal models and characterising B cell immunity using a variety of advanced microscopy and flow cytometry-based techniques.

Project Details

A protective role for memory T lymphocytes localised outside of traditional immune sites has been comprehensively established. However, recent studies have shown memory B cells can similarly take up tissue residence, although the immune benefit for doing so remains unclear. Respiratory syncytial virus (RSV) causes acute respiratory infections in paediatric and geriatric populations associated with significant morbidity, and effective vaccines are currently lacking. This project will assess if immunisation to establish antiviral memory B cells in the lung can combat RSV infection. It will involve: engineering novel influenza-based viral vectors to deliver RSV vaccine antigens, testing in animal models and characterising B cell immunity using a variety of advanced microscopy and flow cytometry-based techniques.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy

Research Node

Doherty Institute

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