Awkward conversations: understanding how exosomes from fatty liver cause metabolic dysfunction
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
|Prof Matthew Wattfirstname.lastname@example.org||Personal web page|
|Dr Paula Miotto|
Summary Our innovative research program seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). We use this information to discover novel targets that can be transitioned to clinical therapeutics. Our research themes are: 1. Understanding how insulin resistance develops in obesity. 2. Understanding how proteins that are secreted by NAFLD / non-alcoholic steatohepatitis (NASH) liver affect metabolism and contributes to the development of type 2 diabetes. 3. Regulation of lipid metabolism: identifying novel proteins that control lipid metabolism and how they are altered in metabolic diseases (e.g. diabetes, cancer).
Project DetailsNon-alcoholic fatty liver disease (NAFLD) and type 2 diabetes are common co-morbidities, suggesting there may be communication between these two conditions. Exosomes are small vesicles that contain a variety of proteins, miRNAs, and lipids that can be delivered to peripheral cell types and alter recipient cell function. We have preliminary evidence showing that exosomes secreted by fatty liver differ from healthy control mice, suggesting that changes in exosome secretion might drive metabolic dysfunction in NAFLD.
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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