Are there additional MAIT cell antigens?

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Sidonia Eckle seckle@unimelb.edu.au (03) 8344 0775 Personal web page
Co-supervisor Email Number Webpage
Dr Lars Kjer-Nielsen lars.kjer@unimelb.edu.au 8344 9910
Dr Alexandra Corbett corbetta@unimelb.edu.au (03) 8344 9914 Personal web page

Summary Our team identified the known natural mucosal-associated invariant T (MAIT) cell antigens, small molecule antigens which derive from microbial riboflavin biosynthesis. We seek to further understand how these antigens are produced and whether other antigens exist.

Project Details

Our team identified the known natural MAIT cell antigens, small molecule antigens which derive from microbial riboflavin biosynthesis. We seek to further understand how these antigens are produced and whether other antigens exist. We have preliminary data for three projects on MAIT cell antigen discovery that we are happy to discuss in detail in person. Broadly speaking, MAIT cell antigen discovery involves in vitro cell line model systems, human blood cell assays, flow cytometry, microbial culture and our proven protein-folding/mass-spectrometry approach.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

McCluskey laboratory: Role of MAIT cells in health and disease

Research Node

Doherty Institute

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