Are there additional MAIT cell antigens?
- Research Opportunity
- PhD, Masters by Research, Honours
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Sidonia Eckle | seckle@unimelb.edu.au | (03) 8344 0775 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Lars Kjer-Nielsen | lars.kjer@unimelb.edu.au | 8344 9910 | |
| Dr Alexandra Corbett | corbetta@unimelb.edu.au | (03) 8344 9914 | Personal web page |
Summary Our team identified the known natural mucosal-associated invariant T (MAIT) cell antigens, small molecule antigens which derive from microbial riboflavin biosynthesis. We seek to further understand how these antigens are produced and whether other antigens exist.
Project Details
Our team identified the known natural MAIT cell antigens, small molecule antigens which derive from microbial riboflavin biosynthesis. We seek to further understand how these antigens are produced and whether other antigens exist. We have preliminary data for three projects on MAIT cell antigen discovery that we are happy to discuss in detail in person. Broadly speaking, MAIT cell antigen discovery involves in vitro cell line model systems, human blood cell assays, flow cytometry, microbial culture and our proven protein-folding/mass-spectrometry approach.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Group / Unit / Centre
McCluskey laboratory: Role of MAIT cells in health and disease
Research Node
Doherty InstituteMDHS Research library
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