Application of systems genomics to analysing the dynamics of Streptococcus pyogenes infection

Summary This project will examine the systems biology of Streptococcus pyogenes subjected to a major and important stress, transition from the ex vivo environment to blood. The research will use various aspects of molecular biology and especially bioinformatics to address the key research questions.

Project Details

The relationship between, and integration of, genomics, transcriptomics, proteomics and metabolomics lies at the heart of understanding how organisms, including bacteria, respond to environmental changes and especially stress, be it physical, immunological or nutritional. This is generically termed systems biology. This project will examine the systems biology of Streptococcus pyogenes subjected to a major and important stress, transition from the ex vivo environment to blood. The research will use various aspects of molecular biology and especially bioinformatics to address the key research questions. Avenues are available to expand this research into looking at immunogenetics within a controlled human infection model.