Apolipoprotein A-I and amyloid fibril formation in disease: how does it change shape and misfold?

Summary We use a wide range of structural biology and biophysical techniques, including X-ray crystallography, cryo-electron microscopy, and analytical ultracentrifugation, to understand the structure, and assembly of proteins into complexes that range from simple homo-dimers to large hetero-oligomers. We are particularly interested in the function and structural mechanisms of multimeric signalling complexes, protein effectors, oligomeric enzymes, and amyloid fibrils.