Antibodies preventing HTLV-1c infection

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Primary Supervisor Email Number Webpage
Professor Damian Purcell dfjp@unimelb.edu.au 8344 6753 Personal web page
Co-supervisor Email Number Webpage
Samantha Grimley

Summary This project will seek to produce monoclonal antibody NAbs against HTLV-1c Env trimers for development of a passive immunotherapy strategy to prevent HTLV transmission. We will also examine the potential of HTLV-1c Env trimers as a candidate preventive vaccine in mice vaccinated with them.

Project Details

The HTLV-1c virus is mostly spread by cell-cell contact with infected T-lymphocytes at the sexual mucosae or following blood exposure. Nevertheless, neutralising antibodies have been reported to block virus transmission. We have engineered and expressed soluble HTLV-1c Env trimers and with these, have developed assays that measure the potency and breadth of HTLV-1c neutralising antibody in patient serum. This project will seek to produce monoclonal antibody NAbs against HTLV-1c Env trimers for development of a passive immunotherapy strategy to prevent HTLV transmission. We will also examine the potential of HTLV-1c Env trimers as a candidate preventive vaccine in mice vaccinated with them.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine


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