Antibodies preventing HTLV-1c infection
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department
- Microbiology and Immunology
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Damian Purcell | dfjp@unimelb.edu.au | 8344 6753 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Samantha Grimley |
Summary This project will seek to produce monoclonal antibody NAbs against HTLV-1c Env trimers for development of a passive immunotherapy strategy to prevent HTLV transmission. We will also examine the potential of HTLV-1c Env trimers as a candidate preventive vaccine in mice vaccinated with them.
Project Details
The HTLV-1c virus is mostly spread by cell-cell contact with infected T-lymphocytes at the sexual mucosae or following blood exposure. Nevertheless, neutralising antibodies have been reported to block virus transmission. We have engineered and expressed soluble HTLV-1c Env trimers and with these, have developed assays that measure the potency and breadth of HTLV-1c neutralising antibody in patient serum. This project will seek to produce monoclonal antibody NAbs against HTLV-1c Env trimers for development of a passive immunotherapy strategy to prevent HTLV transmission. We will also examine the potential of HTLV-1c Env trimers as a candidate preventive vaccine in mice vaccinated with them.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Group / Unit / Centre
Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine
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