Analysing the role of transcriptional regulators in Drosophila and mouse stem cells

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
Number of Master Places Available
Primary Supervisor Email Number Webpage
Prof Gary Hime
Co-supervisor Email Number Webpage
A/Prof Helen Abud

Summary The Hime groups studies regulation of organ development and regeneration in Drosophila and vertebrate tissues. Many differentiated but renewable cell types are derived from relatively small populations of dedicated precursors, or stem cells. The ability to replenish differentiated cells depends on the continued survival and proliferation of their respective stem cell populations. If we are to realise the goals of re-programming tissue differentiation, growing organs for transplantation in vitro, regeneration of damaged organs in vivo and targeted effective treatments for cancer it is essential that we understand the molecules and mechanisms that stem cells utilise for renewal and differentiation.

Project Details

We have shown that transcriptional regulators of epithelial to mesenchymal transition are required in diverse stem cell populations. This role has been conserved through evolution of animals as these proteins can be found in stem cells from Drosophila to mouse.  This project involves using CRISPR and genetically modified Drosophila or mouse intestinal organoid cultures to identify how these proteins regulate stem cell numbers and control the production of differentiated progeny cells. See Horvay et al (2015), Voog et al (2014) and Horvay et al (2011).

Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

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