Age-dependent susceptibility of neurons to RNA virus infection

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Lukasz Kedzierski lukaszk@unimelb.edu.au (03) 8344 0502 Personal web page
Co-supervisor Email Number Webpage
Professor John Fazakerley john.fazakerley@unimelb.edu.au (03) 9731 2261

Summary This project aims to explore mechanisms underlaying the differences between immature and mature neurons in their ability to control RNA virus encephalitis.

Project Details

Central nervous system virus infections are a significant global public health concern. Symptomatic viral encephalitis is reported in 1 in 10,000 people. Neurologic complications, particularly in children, are a major health issue. These include major brain deformities, cognitive impairment, epilepsy and Parkinsonian conditions, and are manifested in up to 50 per cent of survivors of symptomatic encephalitis. Susceptibility to these infections is age-dependent and linked to the ability of the immune system to mount an efficient antiviral response. This project aims to explore mechanisms underlaying the differences between immature and mature neurons in their ability to control RNA virus encephalitis.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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