A stem cell therapy for Hirschsprung Disease
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
|Dr Lincon Stampfirstname.lastname@example.org|
|Prof John Furness|
Summary The healthy gut communicates with the brain and lives in harmony with the many bacteria it contains. Disorders of gut health lead to diabetes and metabolic disease, inadequate nutrition, pain, nausea, poor digestion, liver disease, and digestive diseases. The digestive Physiology and Nutrition Laboratory is working to develop new approaches to treating bowel diseases through neuromodulation, an exciting new approach in which nerves are stimulated to treat disordered function, through drug development and by unravelling the basic mechanisms essential for digestive health. We are also working to understand the reasons why gastrointestinal functions become disordered when there are pathologies of the central nervous system, such as in Parkinson’s Disease.
Hirschsprung disease (HSCR) is a congenital enteric neuropathy characterised by the lack of enteric neurons in the distal bowel, which results in a loss of propulsive motility and life-threatening constipation. Without surgical removal of the defective bowel, the infant dies. Current surgical intervention, while life-saving, frequently results in chronic, long-term complications, including constipation, faecal soiling, and associated psychosocial problems Consequently, alternative treatments are needed.
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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