A novel link between metabolism and host defence: O-GlcNAc glycosylation
- Research Opportunity
- Honours students, Master of Biomedical Science
|Prof Jose Villadangosfirstname.lastname@example.org|
Summary The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by Dendritic Cells, B cells and Macrophages. We are characterizing the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.
Project DetailsO-GlcNAc glycosylation involves addition of a single sugar, β-N-acetylglucosamine, to serine or threonine residues of proteins. It is a unique type of glycosylation found on nuclear and cytoplasmic proteins. The addition and removal of OGlcNAc is catalysed by OGlcNAc transferase (OGT) and OGlcNAse (OGA) respectively. It is a reversible modification akin to phosphorylation. Indeed, OGlcNAc glycosylation occurs in dynamic interplay with phosphorylation, either on the same or adjacent residues. The cross-talk between these two modifications in turn regulates various cellular processes.
Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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