A novel link between metabolism and host defence: O-GlcNAc glycosylation
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Biochemistry and Molecular Biology
- Bio21 Molecular Science and Biotechnology Institute
|Professor Jose Villadangosfirstname.lastname@example.org||Personal web page|
|A/Prof Justine Minternemail@example.com||Personal web page|
Summary In this project we will characterise the function of OGlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens.
O-GlcNAc glycosylation involves addition of a single sugar, β-N-acetylglucosamine, to serine or threonine residues of proteins. It is a unique type of glycosylation found on nuclear and cytoplasmic proteins. The addition and removal of OGlcNAc is catalysed by OGlcNAc transferase (OGT) and OGlcNAse (OGA) respectively. It is a reversible modification akin to phosphorylation. Indeed, OGlcNAc glycosylation occurs in dynamic interplay with phosphorylation, either on the same or adjacent residues. The cross-talk between these two modifications in turn regulates various cellular processes. In this project we will characterise the function of OGlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens. The function of glycosylated proteins will be further studied to understand the relevance of their OGlcNAc status in various immune cell activities. Finally, we will characterize how OGT and OGA recognize their substrates and the mechanisms that regulate their function. These studies may allow us to design therapeutic drugs that target O-GlcNAc glycosylation to manipulate immune responses against pathogens or cancer.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeBio21 Molecular Science and Biotechnology Institute
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