Colorectal Oncogenomics group

Colorectal Oncogenomics group

Led by
Dr Daniel Buchanan,
Department of Pathology
daniel.buchanan@unimelb.edu.au
+61 3 8559 7004

The Colorectal Oncogenomics Group research includes identifying and investigating clinically and biologically relevant subtypes of colorectal cancer (CRC), including both familial and non-familial CRC, that can be identified through genetic, epigenetic, somatic and histopathological characterisation of CRC tumours and their pre-malignant lesions (polyps).

Daniel's group applies cutting-edge, genome-wide genomics for precision public health including:

-  identifying genetic risk factors for colorectal cancer through GWAS and whole genome sequencing studies,
- normal, pre-malignant poly and tumour tissue profiling for DNA methylation (Illumina 450k and EPIC arrays), expression (RNA-seq and Nanostring) and somatic mutations (targeted sequencing and copy number arrays) signatures of risk and underlying aetiology, and
- immune and microbiome profiling through immunohistochemistry and bacterial species profiling, respectively, to understand tumourigenesis, prognosis and response to therapy.